Ciprofloxacin salt and salt co-crystal with dihydroxybenzoic acids

Abstract

The crystal structure of two multi-component crystals of ciprofloxacin [systematic name: 1-cyclo­propyl-6-fluoro-4-oxo-7-(piperazin-1-yl)quinoline-3-carb­­oxy­lic acid], a fluoro­quinolone anti­biotic, namely, ciprofloxacin 2,6-di­hydroxy­benzoate salt, C17H19FN3O3+·C7H5O4−, (I), and ciprofloxacin hydro­chloride–3,5-di­hydroxy­benzoic–water (1/1/1), C17H19FN3O3+·Cl−·C7H6O4·H2O, (II), were determined. In (I) and (II), the ciprofloxacin cations are connected via head-to-tail N—H⋯O hydrogen bonding. Both structures show an alternating layered arrangement between ciprofloxacin and di­hydroxy­benzoic acid.