Capturing a new hydrate polymorph of amodiaquine dihydrochloride dihydrate via heterogeneous crystallisation

Abstract

Herein, we report a new polymorph of amodiaquine dihydrochloride dihydrate obtained via heterogeneous crystallisation. This new polymorph exhibits similarity in molecular conformation as well as in its one-dimensional chain structure with a previously known polymorph, however with a difference in its two-dimensional sheet structure. Although crystal DFT-calculations predict the new form to be thermodynamically less stable compared to the previously known polymorph, the preparation method applied opened up the access to its metastable zone.

Yuda Prasetya Nugraha

Assistant Professor & Researcher in Pharmaceutics

My research interests include structure-property relationship, solid-state characterization of drugs, and solid dosage form developement.