Crystallinity

X-ray diffraction and vibrational spectroscopic studies of the intermolecular interactions on the grinding and compaction behaviours of lopinavir and ritonavir crystals

Lopinavir (LPV) and ritonavir (RTV) are anti-viral drugs used in combination and commonly pre-pared through hot-melt extrusion techniques. Mechanical processes are greatly involved, including blendingand milling. Therefore, the crystal behavior of …